Committee on Science, Engineering, and Public Policy. On Being A Scientist: A Guide to Responsible Conduct in Research, Third Edition. Chapter on Human Participants and Animal Subjects in Research. Washington, DC: National Academy Press, 2009.

Click on the following case study and discussion points:

  • A Change of Protocol
    Discussion Points

    • Description: Explores how the Guide for Use and Care of Laboratory Animals can be applied to this situation.


    Steneck, NH. ORI: Introduction to the Responsible Conduct of Research, Chapter 4: The Welfare of Laboratory Animals. U.S. Department of Health and Human Services.


    Click on the following case study:

  • Fish, Frogs, or Mice

    • Description: Explores how researchers determine which animals to use and when it is appropriate to make changes.


    Macrina, FL. Scientific Integrity: Text and Cases in Responsible Conduct of Research, 4th edition. Chapter 6: Use of Animals in Biomedical Experimentation. Washington, DC: ASM Press, 2014.


    Click on the following Appendix-1 Survey:

  • Survey 8: Animal Subjects

    • Description: Explores the role of the institutional animal care and use committee in reviewing research with animal subjects and encourages trainees to consider their personal criteria for accepting or rejecting the use of animals in research.